Open AccessSynthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents
Author(s) -
Neela Patel,
Vaishali Karkhanis,
Pinkal Patel
Publication year - 2019
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v9i4-s.3327
Subject(s) - piperazine , benzimidazole , chemistry , imidazole , in vivo , anti inflammatory , mannich base , methanol , mannich reaction , carrageenan , proton nmr , stereochemistry , organic chemistry , pharmacology , biochemistry , catalysis , medicine , biology , microbiology and biotechnology
Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent in series.
Keywords: 1,4-disubstituted Piperazine, Anti-inflammatory, Mannich Base.