Open AccessFormulation and evaluation of sustained release matrix tablet of captopril
Author(s) -
Simran Shivdas Pawar,
Prashant S. Malpure,
Santosh S. Surana,
Jayashri S Bhadane
Publication year - 2019
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v9i4-a.3406
Subject(s) - friability , ethyl cellulose , dissolution , xanthan gum , captopril , zero order , fourier transform infrared spectroscopy , chemistry , polymer , matrix (chemical analysis) , materials science , dissolution testing , chromatography , chemical engineering , composite material , mathematics , organic chemistry , first order , medicine , blood pressure , rheology , engineering , radiology
The objective of the present study was to study the effect of polymers on sustained release of Captopril from tablets. Compatibility was studied by Fourier transform infrared spectroscopy and DSC. The tablets were prepared by direct compression technique using Xanthan gum and Ethyl Cellulose. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in-vitro dissolution. Pre and post compression parameters were evaluated and all the parameters were found within the limit. The drug release data were subjected to different models in order to evaluate release kinetics and mechanism of drug release. Formulation F4 was selected as best formulation. The dissolution of formulation F4 can be Shows Non-fickian drug release mechanism.