Open AccessFormulation and evaluation of sustain released matrix tablet of atenolol
Author(s) -
Sonal Sahu,
Rohit Dangi,
Rohit Patidar,
Rukhsaar,
Jagdish Rathi,
Vivek Asati
Publication year - 2019
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v9i1.2281
Subject(s) - atenolol , granulation , friability , dissolution , matrix (chemical analysis) , dosage form , polymer , materials science , chromatography , pharmaceutics , chitosan , pharmacology , chemistry , composite material , medicine , ethyl cellulose , organic chemistry , blood pressure , radiology
Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form. The aim of present investigation was to develop matrix tablets of atenolol using different polymers. Atenolol matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. Tablets of atenolol were prepared utilizing natural polymer chitosan. The formulation F-2 contained chitosan which might have sustained the release since it is also known for its polymeric sustaining effect. The formulation F-2 gave 89.57±0.24% of the drug release in 12 hrs of study.
Keywords: Atenolol, Sustained release Matrix tablets, Direct compression, Wet granulation method.