Open AccessChemical composition and antibacterial activity of essential oil of Senecio graciliflorus
Author(s) -
B. C. Joshi,
Vinod Kumar,
Bhuwan Chandra,
N. D. Kandpal
Publication year - 2019
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v9i1-s.2265
Subject(s) - antimicrobial , antibacterial activity , essential oil , senecio , asteraceae , traditional medicine , chemistry , bacteria , agar diffusion test , food science , biology , botany , microbiology and biotechnology , medicine , genetics
Objective: Among natural products, essential oils and their contituents represent a structurally diverse group of organic compounds with significant antibacterial activity. This study is oriented to assess the therapeutic potential of plant constituents as new antimicrobial drugs.
Methods: Aerial parts of Senecio graciliflorus was steam distilled and analysed by GC and GC-MS for the volatile constituents. Essential oil was studied for their antibacterial activity against Gram-positive and Gram-negative bacteria using agar well diffusion method.
Results: The results revealed that α-pinene and α-thujene are the major constituents of S. graciliflorus oil. In vitro studies showed significant antimicrobial activity against bacterial strains.
Conclusion: This study demonstrated that the oil significantly inhibits the growth of baceria. S. graciliflorus would be another alternative for developing new pharmaceuticals for prevention bacterial diseases and provide a direction for the study of naturally derived drugs.
Keywords: Asteraceae, Senecio graciliflorus, Essential oil, α-Pinene, Antibacterial activity.