Open AccessEvaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals
Author(s) -
Prasant Kumar Sabat
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i6.5165
Subject(s) - histamine , catalepsy , haloperidol , pharmacology , chemistry , guinea pig , phytochemical , traditional medicine , medicine , biochemistry , endocrinology , dopamine
Objective: The current study was planned to evaluate the antiasthamatic effect of Electrohomeopathic medicine Pettorale in various experimental models.
Methods: The antiasthmatic activity of Electrohomeopathic medicine Pettorale was studied on different experimental animals like histamine induced bronchospasm in guinea pig, haloperidol induced catalepsy in rats, egg albumin induced paw anaphylaxis in rats and milk induced leukocytosis in mice.
Conclusion: Preliminary phytochemical screening has revealed the presence of alkaloids, glycosides, carbohydrates, amino acids, proteins, steroids and terpenoids. Petorella exhibited best antihistaminic activity at the dose of 400 mg/kg. It inhibited haloperidol-induced catalepsy, increased leukocyte count and increased eosinophil count due to milk allergen. Antiasthmatic activity of Pettorale may be possible due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.
Keywords: Electrohomeopathy, Pettorale, catalepsy, asthma, histamine