Open AccessAssistance of Gut Microbiota in Depression
Author(s) -
Reeja T Reji,
R. Hari Krishna,
Reeta Kumar
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i6-s.5202
Subject(s) - depression (economics) , antidepressant , medicine , gut flora , microbiome , psychiatry , gut microbiome , mental health , mental illness , quality of life (healthcare) , gut–brain axis , bioinformatics , immunology , biology , anxiety , nursing , economics , macroeconomics
The association between gut microbiota and mental health is a relatively new research topic that has gained traction in recent years. Depression is a serious mental illness and a leading cause of disability, morbidity, and mortality worldwide. Based on the WHO reports, there are approximately 350 million people affected by depression globally. Currently available treatments can temporarily alleviate the symptoms of depressive illness, but these management plans are unable to completely reverse the multifactorial pathology of depression, and the antidepressant medications may produce side effects and adverse drug reactions which may turn down the quality of life of patients. Research has shown that the gut microflora interacts with the brain through various mechanisms, and this leads to the recognition of the microbiome in managing mental health. By unveiling the complexities involved in this area can help to develop novel strategies to treat the depressed patients and to prevent the public from falling to depressive disorder.
Keywords: Gut microbiome, depression, neurotransmitters