Open AccessCapsule Formulation Essay of Herbal Extracts of Trunk Bark of Anogeissus leiocarpus (DC) Guill. Et Perr. (Combretaceae) for the Treatment of Hypertension
Author(s) -
Salfo Ouédraogo,
Charles B Sombié,
Zime Hermine Diawara,
B. Gérard Josias Yameogo,
Tata Kadiatou Traoré,
Mathieu Nitiéma,
Lazare Belemnaba,
Sylvin Ouédraogo,
Rasmané Semdé
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i5.4988
Subject(s) - traditional medicine , capsule , bark (sound) , granulation , medicine , chemistry , biology , materials science , botany , ecology , composite material
The trunks barks of Anogeissus leiocarpus contains multiple antihypertensive components and are, therefore, widely used for the treatment of hypertension.
Objective: This study aimed to formulate capsules containing a freeze-dried aqueous extract of the trunk’s barks.
Methodology: Three (03) capsule formulations were prepared using wet granulation from lyophilised aqueous extract of Anogeissus leiocarpus trunk bark, with different proportions of excipients including Corn starch used as the diluent, Polyvinylpyrrolidone K25 (PVP) used as binding agent and Magnesium stearate used as gliding agents. The filling of capsules was done using a semi-automatic capsule filler with empty capsules of size 3. The flow properties of the granules and the quality control were performed according to the European Pharmacopoeia 10th ed.
Results/Discussion: All granules had good flow properties, and the F1 and F3 formulations had the best pharmaceutics characteristics according to the recommendations of the European Pharmacopoeia 10th ed. The mean levels of phenolic tracers were 0.039±0.0097 mg gallic acid equivalent per capsule (GAE/capsule) for the F1 formulation and 0.059±0.0063 mg GAE/capsule for the F3 formulation.
Conclusion: This study allowed the galenic formulation of capsules based on extracts of good characteristic quality for the treatment of hypertension.
Keywords: Anogeissus leiocarpus, extract, excipients, formulations, capsule