Open AccessFormation development and evaluation of microsphere of sulfasalazine for the treatment inflammatory bowel diseases
Author(s) -
Tanu Tiwari,
Vivek Jain,
Sunil K. Jain,
Pushpendra Kumar Khangar
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i5-s.5120
Subject(s) - sulfasalazine , inflammatory bowel disease , ulcerative colitis , medicine , gastroenterology , microsphere , drug , colitis , colorectal cancer , enema , cancer , disease , pharmacology , chemical engineering , engineering
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder of the small intestine and colon. IBD includes ulcerative colitis (UC) and Crohn’s disease (CD), and it is a main reason for the expansion of colon cancer, referred to as colitis-associated cancer (CAC). Oral colon-targeted microsphere based drug delivery system containing sulfasalazine was prepared, optimized and characterized. The microspheres were effectively prepared by simple emulsification phase-separation technique followed by cross-linking. The formulations were optimized on the basis of drug: polymer ratio, stirring speed, concentration of glutaraldehyde. The prepared microspheres were characterized on the basis of morphology, entrapment efficiency, particle size and in-vitro release.
Keywords: Microspheres, Sulfasalazine, Inflammatory bowel disease, Colon-targeted, Chitosan