Open AccessFormulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride
Author(s) -
T. Gayathri,
M. Venkata Ramana,
N. Rama Rao
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i4.4857
Subject(s) - raloxifene , bioavailability , drug , chemistry , pharmacology , drug delivery , zeta potential , selective estrogen receptor modulator , chromatography , first pass effect , estrogen receptor , breast cancer , medicine , nanotechnology , materials science , nanoparticle , cancer , organic chemistry
Raloxifene hydrochloride (RLX) is a selective Estrogen-receptor modulator used to treat osteoporosis as well as breast and endometrial cancer prevention. The bioavailability of RLX is only 2% due to substantial pre-systemic clearance. The goal of this research was to customise and characterise RLX-loaded self-nanoemulsifying drug-delivery systems (SNEDDS) by using bioactive excipients that impact drug metabolism. The droplet size, zeta potential and drug content determination of optimized formulation (F-06) was found to be 147.5 nm, -28.8, 99.67% respectively. The drug release study from the nano formulation was studied in Phosphate buffer 6.8 for all the formulations F1,F2,F3,F4,F5,F6 and F7. The optimized formulation was found to be F6
Keywords: Raloxifene hydrochloride, nanoemulsion, SNEDDS