Open AccessRecent and Relevant Methodology in the Advancement of Solid Dispersion
Author(s) -
Shruti Talla,
Kamlesh Wadher,
Milind J. Umekar,
Roshni Lohiya
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i4-s.4963
Subject(s) - bioavailability , solubility , dissolution , dispersion (optics) , dosage form , supercritical fluid , materials science , pharmaceutical formulation , water soluble , chemistry , nanotechnology , biochemical engineering , chromatography , pharmacology , organic chemistry , medicine , physics , engineering , optics
Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the pharmaceutical industry are apropos strategies that improve the water solubility of drugs. Solid dispersion has been considered one of the major evolutions in overcoming these issues with several successfully marketed products. Though solid dispersion has been outlined as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersion can be prepared by several methods such as solvent evaporation, melting, and supercritical fluid technology. This review intends to provide an updated overview of the recent trends over the past few years in solid dispersion preparation techniques and polymer used. Along with the various pharmaceutical strategies and future visions for the solubilization of poorly water-soluble drugs
Keywords: Solid dispersion, Bioavailability, Solubility, Dissolution parameters, Polymeric carrier