Open AccessThe Screening models for antiepileptic drugs: A Review
Author(s) -
Pooja Popat Gaikwad,
Vishal S. Adak,
Rajkumar V. Shete
Publication year - 2021
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v11i2-s.4809
Subject(s) - epilepsy , picrotoxin , medicine , strychnine , antiepileptic drug , kainic acid , convulsion , animal model , pharmacology , anticonvulsant , psychiatry , gabaa receptor , glutamate receptor , receptor
Considering the prevalence of epilepsy and the problems associated with currently available antiepileptic drugs like side effects, resistance, safety issue and high cost, herbal medicine with fewer complications could be very appropriate alternative. Therefore in the present study, we have examined the antiepileptic properties of ethanolic extract of leaves in mice using maximal electroshock seizers (MES)test, Pentylenetetrazole (PTZ), induced seizures, strychnine induced convulsion, Isoniazid-induced convulsions, Picrotoxin-induced convulsions, Kainic acid (KA) model etc.There is increased concern on agents for epilepsy disease modification and prevention. To solve these unmet needs, the research scientist must have a thorough knowledge of available animal models of epilepsy so that he can pick up the best model for his research. In this article, we are reviewing the diversity of animal models of epilepsy and their implications in antiepileptic drug discovery.
Keywords: Epilepsy, animal model, seizures,