Open AccessFormulation and evaluation of gas powered systems of cefdinir tablets for controlled release
Author(s) -
Manoj R. Chincholikar,
Jagdish Rathi
Publication year - 2020
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v10i5.4310
Subject(s) - cefdinir , guar gum , magnesium stearate , diluent , ethyl cellulose , sodium bicarbonate , chemistry , granulation , swelling , dissolution , chromatography , methyl cellulose , dosage form , nuclear chemistry , polymer , materials science , cellulose , organic chemistry , composite material , biochemistry , cephalosporin , antibiotics
The present work is aimed to formulate Cefdinir floating tablets using different hydrophilic and hydrophobic polymers like HPMC, Ethyl cellulose, Xanthum gum, guar gum and gas generating agent Sodium bicarbonate. The develop gastro retentive dosage form thatcould retain the agent namely Cefdinir in the stomach for longer periods of time delivering the drug to the site of action, i.e., stomach. HPMC is used as a swelling agent, Guar gum and Xanthum gum is used as binding agent. Ethyl cellulose is used as matrix form agent. PVP is used as a suspending agent. Sodium bicarbonate is used as a gas forming agent. MCC is used as a disintergrant and diluent. Magnesium stearate is used as a lubricant. The prepared Cefdinir tablets will be evaluated for drug content, entrapment efficiency, post compression studies, In-vitro buoyancy studies, swelling index studies, in-vitro dissolution studies, release kinetics, stability studies.All these parameters were found to be within the pharmacopoeial limits. Formulation F5 was selected for drug release and stability study on the basis of appropriate results of post compression study.In vitro dissolution study was carried out and showed controlled release pattern.
Keywords: Gas Powered Systems, Cefdinir, Controlled release, Floating drug delivery.