Open AccessA Review on Pharmacological Aspects of Pyrimidine Derivatives
Author(s) -
Vishal Verma,
Chandra P. Joshi,
Alka Agarwal,
Sakshi Soni,
Udichi Kataria
Publication year - 2020
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v10i5.4295
Subject(s) - pyrimidine , chemistry , formamide , ring (chemistry) , ethyl acetoacetate , pyridine , thio , urea , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogens at positions 1 and 3 in the ring. Pyrimidines are typically synthesized by the “Principal Synthesis” involving cyclization of beta-dicarbonyl compounds with N-C-N compounds. Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidiones, and guanidines to give 2-aminopyrimidines are typical. Pyrimidines can be prepared via the biginelli reaction. Many other methods rely on condensation of carbonyls with diamines for instance the synthesis of 2-Thio-6-methyluracil from thiouria and ethyl acetoacetate or the synthesis of 4-methylpyrimidine with 4, 4-dimethoxy-2-butanone and formamide. Pyrimidine derivatives show antimicrobial activity, anticancer activity, anti-inflammatory activity, antidiabetic, and analgesic activity.1.
Keywords: Pyrimidine derivatives, Synthesis, derivatives and pharmacological activities.