Open AccessCell Biology in Rheumatoid Arthritis
Author(s) -
Lukeshwari Sahu,
Sumathi Rao,
Mahendra Kumar Verma,
Akhilesh Kumar,
Rajendra Sahu,
Dharmendra Kumar,
Chandrakant Yadav
Publication year - 2020
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v10i3-s.4113
Subject(s) - rheumatoid arthritis , immune system , immunology , arthritis , population , cell , medicine , inflammation , autoimmune disease , cell type , biology , antibody , genetics , environmental health
Rheumatoid arthritis (RA) is a systemic autoimmune disease, which affects about 0.33 to 2.65% of the population. In RA Synovium contain various type of immune cell. In which only one cell population cannot cause rheumatoid arthritis that requires more than one cell population. In normal condition, they act as a switch (active or inactive the cell signaling). It controls cell growth, proliferation or metastasizes. In an autoimmune disorder such as rheumatoid arthritis, the immune system mistakenly attacks and destroys the body's cells and tissues. Mostly cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases, this population can expand to constitute 5-20% or more of all synovial cells. Recent investigations in a murine model have demonstrated that cells can have a critical role in the generation of inflammation within the joint.
Keyword: Cell Biology in rheumatic arthritis; Dendrite cell; T-cell; Mast cell; Fibroblastic cell; Macrophages cell.