Open AccessPreparation and Evaluation of Sulfacetamide Sodium Ocusert for Controlled Drug Delivery
Author(s) -
Manisha Nagpal,
Karan Sharma,
Nupur Anand,
Disha Singh,
Ravi Dhawan,
Md. Rageeb Md. Usman,
Navneet Nagpal
Publication year - 2020
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v10i2.3928
Subject(s) - chemistry , bioavailability , ethyl cellulose , nuclear chemistry , methyl cellulose , sodium , chromatography , polymer , cellulose , organic chemistry , pharmacology , medicine
The intent of this research was to formulate and evaluate controlled release ocusert of sulfacetamide sodium for the treatment of bacterial conjunctivitis. Ocusert is a sterile preparation having drug as dispersion or as solution in the polymeric base. Prepared Ocuserts were formulated using hydroxyl propyl methyl cellulose K-15 and Ethyl cellulose as polymers at various concentrations and combinations. Polymeric Films were prepared by mercury casting method using different ratios of polymers. Selected physiochemical properties such as thickness, weight, percentage moisture absorption, and in-vitro release and sterility studies of sulfacetamide sodium ocusert were studied and reported that prepared ocusert resolved the problems of poor bioavailability, frequent dosing and wastage of active ingredient.
Keywords: Hydroxypropyl methyl cellulose K-15, ocusert, sulfacetamide sodium