Open AccessTHE The Effect of Green Tea Infusion (Camellia sinensis) on Histopathology of White Rat (Rattus norvegicus) Liver Sprague dawley Strain Induced by Ethanol
Author(s) -
Muhartono Muhartono,
Nabilah Amirah Salsabila,
Putu Ristyaning Ayu
Publication year - 2020
Publication title -
journal of drug delivery and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2250-1177
DOI - 10.22270/jddt.v10i2-s.4036
Subject(s) - camellia sinensis , histopathology , traditional medicine , green tea , ethanol , significant difference , liver tissue , black tea , zoology , medicine , biology , food science , botany , pathology , biochemistry
Aims: This research aims to determine the effect of green tea infusion (Camellia sinensis) on the hitopathology of white rat liver induced by ethanol.
Method: This study used 30 rats divided into 5 groups as follow negative control group (K1) given aquades, positive control group (K2) given 20% 2 mL/day peroral, treatment group 1, 2, 3 (P1, P2, P3) given 20% ethanol 2 mL/day peroral followed by green tea infusion with doses 0,375 g/day, 0,75 g/day, and 1,5 g/day single dose per oral for 14 days. The the liver of the rat is taken for microscopic examination. The mean Manja Roenigk scores obtained were K1=1,16, K2=3,36, P1=2,8, P2=2,68, and P3=2,56. Data were tested with the Kruskal-wallis test followed by Mann whitney’s post hoc test.
Results: The results showed a significant mean difference between positive group (K2) and the treatment group P1, P2, and P3. There is no significant mean difference between P1-P2, P1-P3, and P2-P3 which means giving green tea infusion (Cameliia sinensis) in P2 and P3 gave almost the same effect as P1.
Conclusion: There is an effect of giving green tea infusion (Camellia sinensis) to the histopathology of white rat liver induced by ethanol.
Keywords: antioxidants, ethanol, green tea infusion, liver histopathology.