Open AccessEstablishment of blending control for Hand operated Double Cone Blender
Author(s) -
Bayya Subba Rao,
A. V. Raveendran,
Ratnakar Baki,
Adithya Jinuka
Publication year - 2018
Publication title -
international journal of drug regulatory affairs
Language(s) - English
Resource type - Journals
eISSN - 2321-7162
pISSN - 2321-6794
DOI - 10.22270/ijdra.v6i2.233
Subject(s) - potassium permanganate , diluent , potassium , cone (formal languages) , mathematics , chemistry , materials science , chromatography , nuclear chemistry , algorithm , organic chemistry
In the current study, a fundamental approach is used to establish operation procedure, for a hand operated double cone blender. Initially, assuming for a potent drug, where in, the strength of the drug is very less in the final dosage form, a one percent concentration of potassium permanganate with respect to final one kilogram of blended powder using starch as diluent was planned. With a kind of geometric progression method, at a rate of 10 rotations per minute, the final outcome of the uniform distribution of the potassium permanganate was found to be for at least for fourteen hours of rotations, leading to concentration range of potassium permanganate 0.08 ± 0.025 mg per mg of final blended powder.