Open AccessREVIEW ON OCULAR DRUG DELIVERY SYSTEM AND ITS DEVICES
Author(s) -
Nikhil Gulati,
Vanya Dwivedi
Publication year - 2018
Publication title -
international journal of drug regulatory affairs
Language(s) - English
Resource type - Journals
eISSN - 2321-7162
pISSN - 2321-6794
DOI - 10.22270/ijdra.v2i3.145
Subject(s) - drug delivery , delivery system , drug , controlled release , medicine , implant , ethylene vinyl acetate , patient compliance , eye care , ophthalmology , biomedical engineering , surgery , nanotechnology , materials science , pharmacology , copolymer , polymer , optometry , emergency medicine , composite material
Ocular drug delivery system for the treatment of eye diseases has become popular and feasible in the past few years. Improving ocular contact time, enhancing corneal permeability and site specificity are the key points for the optimization of ocular drug delivery. Use of polymers such as ethylene vinyl acetate copolymer can increase the solution viscosity and decrease the drainage of solution, thereby increasing the contact time and its bioavailabilty. There are various types of ocular drug release system such as ocusert, contact lenses, diffusional inserts which falls under the category of non-erodible ocular controlled release system, lacrisert, soluble ocular delivery implant(SODI), minidisc which falls under the category of erodible ocular controlled release system; nanoparticles; liposomes.
Episcleral, intrascleral and suprachoroidal routes have the advantage of bypassing the main barriers to topical drug penetration. This type of delivery system provides a controlled release of drug for a long period of time. This type of delivery system has good patient compliance. Acuvue, lacrisert; biomedics are the most common marketed products of ocular drug delivery system.