Open AccessEFFECTS OF PH, SALT, TEMPERATURE ON CONVENTIONAL LIPOSOMES SIZE ENLARGEMENT ANALYZED BY OPTICAL MICROSCOPE
Author(s) -
Sandip Maurya
Publication year - 2018
Publication title -
international journal of drug regulatory affairs
Language(s) - English
Resource type - Journals
eISSN - 2321-7162
pISSN - 2321-6794
DOI - 10.22270/ijdra.v1i1.104
Subject(s) - liposome , zeta potential , optical microscope , particle size , salt (chemistry) , materials science , dispersion (optics) , chemistry , microscope , chromatography , analytical chemistry (journal) , composite material , nanotechnology , optics , scanning electron microscope , organic chemistry , nanoparticle , physics
The objective of the present study was to investigate the effects of experimental conditions like pH, salt, temperature on the interactions of conventional liposomes. The model drug Stavudine was entrapped in the liposomes composed of Phosphotidyl Choline and cholesterol in the ratio of 200mg: 80mg and prepared by thin film hydration method. Liposomes preparation was characterized and compared for particle size, mean dispersion, entrapment efficiency, Zeta potential and the size enlargement studies were carried out in optical microscope by using Magnus.