Open AccessEvaluation of Hepatoprotective Activity of Leaves Extract of Pithecellobium Dulce In Experimental Animals
Author(s) -
Komal Sul,
V. J. Chaware,
Vivekkumar K. Redasani
Publication year - 2021
Publication title -
asian journal of pharmaceutical research and development
Language(s) - English
Resource type - Journals
ISSN - 2320-4850
DOI - 10.22270/ajprd.v9i4.985
Subject(s) - traditional medicine , food science , biology , chemistry , medicine
Objective: To evaluate the hepatoprotective activity of leaves extract of Pithecellobiumdulce in experimental rats.
Methods: For the generation of Hepatotoxicity ,paracetamol (2g/kg) was administered orally for 7days, accompanied by a 7-day dose of Ethanolic extract of Pithecellobiumdulceleaves(100mg/kg, 200mg/kg, and400mg/kg, p.o.)using 1 % w/v CMC as a vehicle.
Results: From the present investigation, it was observed that ethanolic extract of Pithecellobium dulce have shown significant reduction in serum glutamate oxaloacetate transminase (SGOT),serum glutamate pyruvate transminase (SGPT),alkaline phosphatase (ALP) triglyceride, bilirubin level in paracetamol induced hepatotoxicity.
Conclusion: The findings in this study revealed the effectiveness of ethanolic extract of Pithecellobiun dulce against hepatotoxicity activity.