Open AccessSynthesis and Spectral Studies of Hydantoin Derivativatives of Imidazo [2,1-b][1,3,4] Thiadiazoles
Author(s) -
Ravi S. Naik
Publication year - 2022
Publication title -
international journal for research in applied science and engineering technology
Language(s) - English
Resource type - Journals
ISSN - 2321-9653
DOI - 10.22214/ijraset.2022.40510
Subject(s) - thiadiazoles , hydantoin , knoevenagel condensation , molecule , chemistry , condensation , condensation reaction , stereochemistry , phenacyl , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics
The present article describes the synthesis of Imidazo[2,1-b][1,3,4]thiadiazoles bearing pharmacologically important hydantoin molecules. To synthesize the targeted molecules several imidazothiadiazoles were prepared by condensation of 2- Amino-5-(4-fluorobenzyl)-1,3,4thiadiazole with phenacyl bromides. Which were subsequently subjected to Knoevenagel condensation to afford the hydantoin derivatives. Structures of newly synthesized molecules were confirmed by IR, NMR and Mass spectral studies. Keywords: Thiadiazole, Imidazothiadiazole, hydantoin, Vilsmeier Haack reaction