Open AccessPreliminary Study on the Effect of Quinolone against Rec A Protein for the Possible Role in the Treatment of Tuberculosis through Molecular Docking
Author(s) -
Priyanka Gautam
Publication year - 2021
Publication title -
international journal for research in applied science and engineering technology
Language(s) - English
Resource type - Journals
ISSN - 2321-9653
DOI - 10.22214/ijraset.2021.36198
Subject(s) - protein data bank (rcsb pdb) , docking (animal) , mycobacterium tuberculosis , quinolone , tuberculosis , ligand (biochemistry) , computational biology , protein data bank , drug discovery , in vivo , chemistry , biology , protein structure , stereochemistry , medicine , biochemistry , genetics , receptor , pathology , antibiotics , nursing
Tuberculosis is a type of ancient, chronic disease which affects humans and caused by Mycobacterium tuberculosis. They affect the lungs and other organs. The treatment is curable but in some cases it is fatal if not treated properly. The molecular docking method was used to see the interaction of the protein with the ligand. Thus, molecular docking was used to analyse the Rec A (PDB ID 1U94) target protein with their known type of ligand by using molecular docking tools. The Rec A (PDB ID 1U94) structure of protein was downloaded through online database. The best ligand after molecular docking was Quinolone, which may act as a drug after in vitro and in vivo studies.