Open AccessCOVID-19 and Diabetes Mellitus: A Complex Interplay
Author(s) -
Gopala Koneru,
Nayera A. Abd-elhamed,
Nouran Elsedfy,
Hania A. Abdellatif,
Fatmaalzharaa F. Mohamed,
Esraa H. Bahnasawy,
Nayera K. Mousa,
Aml Eisa,
Yassmin Z. Basheer,
Esraa Sayed,
Farah F. Mohamed,
Walaa R. Ali,
Hadir A. Soliman,
Ashrakt A. Eltabary,
Noorhan M. Sayed,
Nourhan H. Nasr,
Nour S. Khairallah
Publication year - 2021
Publication title -
journal of pure and applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.149
H-Index - 16
eISSN - 2581-690X
pISSN - 0973-7510
DOI - 10.22207/jpam.15.2.16
Subject(s) - diabetes mellitus , asymptomatic , pandemic , covid-19 , coronavirus , medicine , immune system , immunology , intensive care medicine , virology , disease , endocrinology , infectious disease (medical specialty) , outbreak
COVID-19 pandemic, which caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS- CoV-2), puts the entire world in an unprecedented crisis, leaving behind huge human losses and serious socio-economical damages. The clinical spectrum of COVID-19 varies from asymptomatic to multi-organ manifestations. Diabetes mellitus (DM) is a chronic inflammatory condition, which associated with metabolic and vascular abnormalities, increases the risk for SARS-CoV-2 infection, severity and mortality. Due to global prevalence, DM effect on COVID-19 outcomes as well as the potential mechanisms by which DM modulates the host-viral interactions and host-immune responses are discussed in this review. This review also highlights the effects of anti-diabetic drugs on treatment of SARS-CoV-2 infection and vice versa.