Open AccessChrono pharmacotherapy: A pulsatile Drug Delivery
Author(s) -
Huma Hameed,
Arwa Khalid,
Fazala Khalid,
Rabeea F. Khan,
Akhtar Rasul
Publication year - 2015
Publication title -
pakistan journal of pharmaceutical research (online)
Language(s) - English
Resource type - Journals
eISSN - 2414-8334
pISSN - 2410-6275
DOI - 10.22200/pjpr.2015125-32
Subject(s) - pulsatile flow , drug delivery , medicine , drug , ulcerative colitis , dosing , pharmacology , circadian rhythm , pharmacotherapy , intensive care medicine , targeted drug delivery , disease , chemistry , organic chemistry
Chronopharmacotherapy refers to a treatment in which controlled drug delivery is achieved according to circadian rhythms of disease by enhancing therapeutic outcomes and minimizing side effects. Colon targeting has gained great importance not only for the treatment of local diseases such as Crohn’s disease, inflammatory bowel disease and ulcerative colitis but also very important in systemic delivery of proteins/peptides, antiasthmatic drugs, antidiabetic agents and antihypertensive drugs, which mostly show their efficacy based on circadian rhythms of the body.Colon drug delivery is one of the difficult approaches to achieve the targeted and desired outcomes through pulsatile drug delivery by avoiding dose dumping.The main reasonbehind the use of pulsatile delivery is provision ofconstant drug release where a zero-order release is notpreferred. Chronopharmacotherapy in colon targeting play its role bymany systems such ascapsular systems, pulsatile system and osmotic systems, which are based on use of rupturable membranes and biodegradable polymers.The objective of this review article is to provide latest knowledge about drugs with chrono-pharmacological behavior entails night time dosing specially to the colon.