Open Access3C. 3-Ketosteroid receptors in GtoPdb v.2021.3
Author(s) -
Derek W. Cain,
John A. Cidlowski,
Dean P. Edwards,
Peter J. Fuller,
Sandra L. Grimm,
Sean M. Hartig,
Carol A. Lange,
Robert H. Oakley,
Jennifer K. Richer,
Carol A. Sartorius,
Marc J. Tetel,
Nancy L. Weigel,
Morag J. Young
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f98/2021.3
Subject(s) - endocrinology , medicine , dihydrotestosterone , receptor , estrone , testosterone (patch) , steroid , hormone , corticosterone , aldosterone , chemistry , steroid hormone , biology , androgen
Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [74, 215, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol.