1I. Vitamin D receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database | Zendy

Sylvia Christakos | Zendy

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1I. Vitamin D receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Author(s) -

Sylvia Christakos

Publication year - 2019

Publication title -

iuphar/bps guide to pharmacology cite

Language(s) - English

Resource type - Journals

ISSN - 2633-1020

DOI - 10.2218/gtopdb/f90/2019.4

Subject(s) - pregnane x receptor , calcitriol receptor , receptor , constitutive androstane receptor , pharmacology , chemistry , nuclear receptor , retinoid x receptor , hormone , endocrinology , medicine , biochemistry , transcription factor , gene

Vitamin D (VDR), Pregnane X (PXR) and Constitutive Androstane (CAR) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [47]) are members of the NR1I family of nuclear receptors, which form heterodimers with members of the retinoid X receptor family. PXR and CAR are activated by a range of exogenous compounds, with no established endogenous physiological agonists, although high concentrations of bile acids and bile pigments activate PXR and CAR [47].

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