Open Access3.6.5.2 Small monomeric GTPases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Elena Faccenda
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f896/2019.4
Subject(s) - gtpase , heterotrimeric g protein , guanosine , guanosine triphosphate , gtp' , biochemistry , gtp binding protein regulators , protein subunit , chemistry , subfamily , guanosine diphosphate , triphosphatase , hydrolase , enzyme , g protein , biology , receptor , gene
Small G-proteins, are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases.