Open Access1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Donald P. McDonnell,
Rachid Safi
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f89/2019.4
Subject(s) - nuclear receptor , farnesoid x receptor , receptor , liver x receptor , estrogen related receptor gamma , pseudogene , subfamily , hormone , retinoid x receptor , medicine , pharmacology , endocrinology , chemistry , biology , biochemistry , gene , transcription factor , genome
Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [68]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [71].