Open AccessBlood coagulation components in GtoPdb v.2021.2
Author(s) -
Szu Shen Wong
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f853/2021.2
Subject(s) - coagulation , thrombin , proteolysis , coagulation cascade , proteases , chemistry , tissue factor , platelet , prothrombinase , integrin , microbiology and biotechnology , immunology , biochemistry , medicine , enzyme , biology , receptor
Coagulation as a process is interpreted as a mechanism for reducing excessive blood loss through the generation of a gel-like clot local to the site of injury. The process involves the activation, adhesion (see Integrins), degranulation and aggregation of platelets, as well as proteins circulating in the plasma. The coagulation cascade involves multiple proteins being converted to more active forms from less active precursors (for example, prothrombin [Factor II] is converted to thrombin [Factor IIa]), typically through proteolysis (see Proteases). Listed here are the components of the coagulation cascade targeted by agents in current clinical usage or at an advanced level of development.