Open AccessPeptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2
Author(s) -
Stephanie Annett,
Tracy Robson
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f845/2021.2
Subject(s) - fkbp , isomerase , prolyl isomerase , peptidylprolyl isomerase , cis trans isomerases , proline , pin1 , chemistry , stereochemistry , biochemistry , folding (dsp implementation) , trans acting , isomerization , peptide bond , enzyme , biology , gene , amino acid , catalysis , mutant , electrical engineering , engineering
Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [59], and family members have been targetted for immunosuppressant effects.