Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2 | Zendy

Stephanie Annett | Zendy; Tracy Robson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2

Author(s) -

Stephanie Annett,

Tracy Robson

Publication year - 2021

Publication title -

iuphar/bps guide to pharmacology cite

Language(s) - English

Resource type - Journals

ISSN - 2633-1020

DOI - 10.2218/gtopdb/f845/2021.2

Subject(s) - fkbp , isomerase , prolyl isomerase , peptidylprolyl isomerase , cis trans isomerases , proline , pin1 , chemistry , stereochemistry , biochemistry , folding (dsp implementation) , trans acting , isomerization , peptide bond , enzyme , biology , gene , amino acid , catalysis , mutant , electrical engineering , engineering

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [59], and family members have been targetted for immunosuppressant effects.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research