Open Access1A. Thyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Douglas Forrest,
Anthony N. Hollenberg,
Paul Webb
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f84/2019.4
Subject(s) - thyroid hormone receptor , triiodothyronine , receptor , hormone , nuclear receptor , thyroid hormone receptor beta , endocrinology , medicine , thyroid , chemistry , hormone receptor , pharmacology , transcription factor , biochemistry , cancer , gene , breast cancer
Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [10]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and cardiovascular homeostasis. TRs are activated by thyroxine (T4) and thyroid hormone (triiodothyronine). Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. NH-3 has been described as an antagonist at TRs with modest selectivity for TRβ [38].