Open AccessKisspeptin receptor (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Anthony P. Davenport,
Janet J. Maguire,
Edward J. Mead,
Adam J. Pawson
Publication year - 2020
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f34/2020.4
Subject(s) - kisspeptin , receptor , endocrinology , prolactin , medicine , endogeny , chemistry , pharmacology , biology , hormone
The kisspeptin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the kisspeptin receptor [9]), like neuropeptide FF (NPFF), prolactin-releasing peptide (PrP) and QRFP receptors (provisional nomenclature) responds to endogenous peptides with an arginine-phenylalanine-amide (RFamide) motif. kisspeptin-54 (KP54, originally named metastin), kisspeptin-13 (KP13) and kisspeptin-10 (KP10) are biologically-active peptides cleaved from the KISS1 (Q15726) gene product. Kisspeptins have roles in, for example, cancer metastasis, fertility/puberty regulation and glucose homeostasis.