Glucagon receptor family in GtoPdb v.2021.3 | Zendy

D. Bataille | Zendy; Susan L.F. Chan | Zendy; Philippe Delagrange | Zendy; Daniel J. Drucker | Zendy; Burkhard Göke | Zendy; Rebecca Hills | Zendy; Kelly E. Mayo | Zendy; Laurence J. Miller | Zendy; Roberto Salvatori | Zendy; Bernard Thorens | Zendy

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Glucagon receptor family in GtoPdb v.2021.3

Author(s) -

D. Bataille,

Susan L.F. Chan,

Philippe Delagrange,

Daniel J. Drucker,

Burkhard Göke,

Rebecca Hills,

Kelly E. Mayo,

Laurence J. Miller,

Roberto Salvatori,

Bernard Thorens

Publication year - 2021

Publication title -

iuphar/bps guide to pharmacology cite

Language(s) - English

Resource type - Journals

ISSN - 2633-1020

DOI - 10.2218/gtopdb/f29/2021.3

Subject(s) - glucagon , secretin family , secretin , receptor , endocrinology , medicine , glucagon like peptide 1 , peptide hormone , hormone , peptide , chemistry , biology , secretion , vasoactive intestinal peptide , biochemistry , neuropeptide , diabetes mellitus , type 2 diabetes

The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [162]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [119]. For a recent review on the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the associated signaling events see de Graaf et al., 2016 [89].

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