Open AccessGlucagon receptor family in GtoPdb v.2021.3
Author(s) -
D. Bataille,
Shyue An Chan,
Philippe Delagrange,
Daniel J. Drucker,
Burkhard Göke,
Rebecca Hills,
Kelly E. Mayo,
Laurence J. Miller,
Roberto Salvatori,
Bernard Thorens
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f29/2021.3
Subject(s) - glucagon , secretin family , secretin , receptor , endocrinology , medicine , glucagon like peptide 1 , peptide hormone , hormone , peptide , chemistry , biology , secretion , vasoactive intestinal peptide , biochemistry , neuropeptide , diabetes mellitus , type 2 diabetes
The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [162]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [119]. For a recent review on the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the associated signaling events see de Graaf et al., 2016 [89].