Open AccessAdhesion Class GPCRs in GtoPdb v.2021.3
Author(s) -
Demet Araç-Özkan,
Gabriela Aust,
Tom I. Bonner,
Heike Cappallo-Obermann,
Caroline Formstone,
Jörg Hamann,
Breanne L. Harty,
Henrike O. Heyne,
Christiane Kirchhoff,
Barbara Knapp,
Arunkumar Krishnan,
Tobias Langenhan,
Diana Le Duc,
HsiHsien Lin,
David C. Martinelli,
Kelly R. Monk,
Xianhua Piao,
Simone Prömel,
Torsten Schöneberg,
Helgi B. Schiöth,
Kathleen Singer,
Martin Stacey,
Yuri A. Ushkaryov,
Uwe Wolfrum,
Lei Xu
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f17/2021.3
Subject(s) - g protein coupled receptor , receptor , adhesion , biology , cadherin , microbiology and biotechnology , chemistry , computational biology , biochemistry , organic chemistry , cell
Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [9] containing a GPCR proteolytic site. The N-terminus often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [101, 403]. Several receptors have been suggested to function as mechanosensors [309, 280, 383, 35]. The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [122].