Open AccessClass A Orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Stephen Alexander,
Jim Battey,
Helen E. Benson,
Richard V. Benya,
Tom I. Bonner,
Anthony P. Davenport,
Satoru Eguchi,
Anthony J. Harmar,
Nicholas D. Holliday,
Robert T. Jensen,
Sadashiva S. Karnik,
Evi Kostenis,
Wen Chiy Liew,
Amy E. Monaghan,
Chido Mpamhanga,
Richard Neubig,
Adam J Pawson,
JeanPhilippe Pin,
Joanna L. Sharman,
Michael Spedding,
Eliot R. Spindel,
Leigh A. Stoddart,
Laura Storjohann,
Walter G. Thomas,
Kalyan Tirupula,
Patrick Vanderheyden
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f16/2019.4
Subject(s) - g protein coupled receptor , gpr18 , endogeny , cannabinoid receptor , pharmacology , biology , computational biology , receptor , genetics , biochemistry , antagonist
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [191], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [148]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.Table 1: Class A orphan GPCRs with putative endogenous ligandsGPR3GPR4GPR6GPR12GPR15GPR17GPR20 GPR22GPR26GPR31GPR34GPR35GPR37GPR39 GPR50GPR63GRP65GPR68GPR75GPR84GPR87 GPR88GPR132GPR149GPR161GPR183LGR4LGR5 LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).