Open AccessSLC28 and SLC29 families of nucleoside transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
James R. Hammond
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f149/2019.4
Subject(s) - transporter , nucleoside , tenofovir , endogeny , chemistry , solute carrier family , pharmacology , nucleobase , biology , biochemistry , virology , gene , dna , human immunodeficiency virus (hiv)
Nucleoside transporters are divided into two families, the sodium-dependent, concentrative solute carrier family 28 (SLC28) and the equilibrative, solute carrier family 29 (SLC29). The endogenous substrates are typically nucleosides, although some family members can also transport nucleobases and organic cations.