SLC22 family of organic cation and anion transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database | Zendy

Bruno Hagenbuch | Zendy

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SLC22 family of organic cation and anion transporters (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Author(s) -

Bruno Hagenbuch

Publication year - 2019

Publication title -

iuphar/bps guide to pharmacology cite

Language(s) - English

Resource type - Journals

ISSN - 2633-1020

DOI - 10.2218/gtopdb/f146/2019.4

Subject(s) - transporter , organic anion transporter 1 , organic anion transporting polypeptide , extracellular , organic cation transport proteins , chemistry , intracellular , pharmacology , database , biology , biochemistry , computer science , gene

The SLC22 family of transporters is mostly composed of non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role in drug disposition. The family may be divided into three subfamilies based on the nature of the substrate transported: organic cations (OCTs), organic anions (OATs) and organic zwiterrion/cations (OCTN). Membrane topology is predicted to contain 12 TM domains with intracellular termini, and an extended extracellular loop at TM 1/2.

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