Open AccessSLC6 neurotransmitter transporter family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Author(s) -
Stefan Bröer,
Gary Rudnick
Publication year - 2019
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f144/2019.4
Subject(s) - transporter , neurotransmitter transporter , monoamine neurotransmitter , neurotransmitter , sodium , chemistry , amino acid , gaba transporter , aquifex aeolicus , glycine , pharmacology , biochemistry , biology , escherichia coli , gene , receptor , serotonin , organic chemistry
Members of the solute carrier family 6 (SLC6) of sodium- and (sometimes chloride-) dependent neurotransmitter transporters [29, 22, 70] are primarily plasma membrane located and may be divided into four subfamilies that transport monoamines, GABA, glycine and neutral amino acids, plus the related bacterial NSS transporters [99]. The members of this superfamily share a structural motif of 10 TM segments that has been observed in crystal structures of the NSS bacterial homolog LeuTAa, a Na+-dependent amino acid transporter from Aquiflex aeolicus [126] and in several other transporter families structurally related to LeuT [45].