SLC6 neurotransmitter transporter family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database | Zendy

Stefan Bröer | Zendy; Gary Rudnick | Zendy

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SLC6 neurotransmitter transporter family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Author(s) -

Stefan Bröer,

Gary Rudnick

Publication year - 2019

Publication title -

iuphar/bps guide to pharmacology cite

Language(s) - English

Resource type - Journals

ISSN - 2633-1020

DOI - 10.2218/gtopdb/f144/2019.4

Subject(s) - transporter , neurotransmitter transporter , monoamine neurotransmitter , neurotransmitter , sodium , chemistry , amino acid , gaba transporter , aquifex aeolicus , glycine , pharmacology , biochemistry , biology , escherichia coli , gene , receptor , serotonin , organic chemistry

Members of the solute carrier family 6 (SLC6) of sodium- and (sometimes chloride-) dependent neurotransmitter transporters [29, 22, 70] are primarily plasma membrane located and may be divided into four subfamilies that transport monoamines, GABA, glycine and neutral amino acids, plus the related bacterial NSS transporters [99]. The members of this superfamily share a structural motif of 10 TM segments that has been observed in crystal structures of the NSS bacterial homolog LeuTAa, a Na+-dependent amino acid transporter from Aquiflex aeolicus [126] and in several other transporter families structurally related to LeuT [45].

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