Open AccessSLC66 Lysosomal amino acid transporters in GtoPdb v.2021.2
Author(s) -
Gergely Gyimesi,
Matthias A. Hediger
Publication year - 2021
Publication title -
iuphar/bps guide to pharmacology cite
Language(s) - English
Resource type - Journals
ISSN - 2633-1020
DOI - 10.2218/gtopdb/f1048/2021.2
Subject(s) - transporter , solute carrier family , biology , excitatory amino acid transporter , atp binding cassette transporter , computational biology , biochemistry , microbiology and biotechnology , chemistry , gene , receptor , glutamate receptor
This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin). The functions of the 3 remaining members of the family are undetermined.