Open AccessNovel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: a pilot study
Author(s) -
Prathap Jayaram,
Gu Eon Kang,
Brett Heldt,
Olumide F Sokunbi,
Bo Song,
Peter Yeh,
Max Epstein,
Theodore B. Shybut,
Brendan Lee,
Bijan Najafi
Publication year - 2021
Publication title -
regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 63
eISSN - 1746-076X
pISSN - 1746-0751
DOI - 10.2217/rme-2021-0032
Subject(s) - medicine , platelet rich plasma , osteoarthritis , range of motion , prospective cohort study , physical therapy , cohort , quality of life (healthcare) , gait , cohort study , platelet , pathology , alternative medicine , nursing
Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.