Open AccessSpondylodiscitis due to Cutibacterium acnes following lumbosacral intradiscal biologic therapy: a case report
Author(s) -
Nicholas Beatty,
Cole Lutz,
Kwadwo BoachieAdjei,
Teresita A Leynes,
Christopher Lutz,
Gregory E. Lutz
Publication year - 2019
Publication title -
regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 63
eISSN - 1746-076X
pISSN - 1746-0751
DOI - 10.2217/rme-2019-0008
Subject(s) - medicine , spondylodiscitis , back pain , lumbosacral joint , discitis , surgery , low back pain , lumbar , biopsy , radiology , pathology , magnetic resonance imaging , alternative medicine
A 40-year-old woman with a history of chronic low back pain underwent a fluoroscopically guided intradiscal platelet-rich plasma injection (PRP) at the L5–S1 level. She subsequently developed progressive low back pain, night sweats and decreased ability to ambulate. Laboratory work-up revealed elevated acute phase reactants and imaging revealed L5–S1 intervertebral disc and vertebral end-plate abnormalities highly suggestive of spondylodiscitis. Computed tomography-guided aspiration and biopsy cultures grew Cutibacterium acnes and the patient was subsequently treated with intravenous antibiotics without surgical management. To the best of our knowledge, this is the first published case of lumbar spondylodiscitis following an intradiscal PRP injection, and brings to the forefront several clinically relevant issues including the antimicrobial effects of PRP, the role of C. acnes in spine infections and the ideal treatment protocol for intradiscal biologics in order to minimize morbidity and optimize functional outcomes.