Open AccessPositive association of SCD1 genetic variation and metabolic syndrome in dialysis patients in China
Author(s) -
Yanyan Guo,
Zhuo Xiong,
Meiling Su,
Limin Huang,
Jinlan Liao,
Xin Hu,
Xiaoyan Huang,
Zuying Xiong
Publication year - 2020
Publication title -
personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.489
H-Index - 31
eISSN - 1744-828X
pISSN - 1741-0541
DOI - 10.2217/pme-2019-0020
Subject(s) - medicine , single nucleotide polymorphism , dialysis , metabolic syndrome , snp , genotype , gene , genetics , biology , obesity
Aim: Metabolic syndrome (MetS) diagnosed in the dialysis patients is increasingly reported which worsens the prognosis of the renal diseases. The relationship of SCD1 with MetS is largely unknown. The purpose of this study was to investigate the relationship between SCD1 polymorphism and MetS in dialysis patients. Methods: A cross-sectional study was conducted on 323 Chinese dialysis patients, and the correlation between the seven SNPs of SCD1 gene (rs10883465, rs2060792, rs1502593, rs522951, rs3071, rs3978768 and rs1393492) and MetS was analyzed. Results: One tag-SNP (rs1393492) has significantly associated with the prevalence of MetS. Dialysis patients with rs1393492 AA genotype of SCD1 are more prone to MetS (p = 0.021). Conclusion: This study shows that the rs1393492 variations of SCD1 gene are related with the development of MetS in Chinese dialysis patients.