Toward Health Technology Assessment of Whole-Genome Sequencing Diagnostic Tests: Challenges and Solutions | Zendy

Katherine Payne | Zendy; Martin Eden | Zendy; Niall Davison | Zendy; Egbert Bakker | Zendy

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Toward Health Technology Assessment of Whole-Genome Sequencing Diagnostic Tests: Challenges and Solutions

Author(s) -

Katherine Payne,

Martin Eden,

Niall Davison,

Egbert Bakker

Publication year - 2017

Publication title -

personalized medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.489

H-Index - 31

eISSN - 1744-828X

pISSN - 1741-0541

DOI - 10.2217/pme-2016-0089

Subject(s) - multidisciplinary approach , perspective (graphical) , health care , health technology , data science , medicine , management science , computer science , engineering , sociology , political science , artificial intelligence , social science , law

Whole-genome sequencing (WGS) is being applied within research settings across Europe to develop genomic WGS-based diagnostic tests. The focus of this perspective paper is to describe if, and how, current approaches of health technology assessment could be applied to WGS-based diagnostic tests. This perspective draws on the collective view from a trans-European multidisciplinary consortium of methodologists, clinicians and scientists. Specific challenges can be described by using the PICO (population, intervention, comparator, outcome) framework to inform health technology assessment. Practical solutions are suggested which require joined-up, multidisciplinary working across healthcare systems using existing expert networks so that emergent issues for the health technology assessment of WGS can be met in a timely fashion.

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