Biomarkers of Hippocampal Gene Expression in a Mouse Restraint Chronic Stress Model | Zendy

Massimo Ubaldi | Zendy; Eugenia Ricciardelli | Zendy; Lorenza Pasqualini | Zendy; Giuseppina Sannino | Zendy; Laura Soverchia | Zendy; Barbara Ruggeri | Zendy; Silvia Falcinelli | Zendy; Alessandra Renzi | Zendy; Colleen Ludka | Zendy; Roberto Ciccocioppo | Zendy; Gary Hardiman | Zendy

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Biomarkers of Hippocampal Gene Expression in a Mouse Restraint Chronic Stress Model

Author(s) -

Massimo Ubaldi,

Eugenia Ricciardelli,

Lorenza Pasqualini,

Giuseppina Sannino,

Laura Soverchia,

Barbara Ruggeri,

Silvia Falcinelli,

Alessandra Renzi,

Colleen Ludka,

Roberto Ciccocioppo,

Gary Hardiman

Publication year - 2015

Publication title -

pharmacogenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.541

H-Index - 91

eISSN - 1744-8042

pISSN - 1462-2416

DOI - 10.2217/pgs.15.3

Subject(s) - chronic stress , medicine , context (archaeology) , anxiety , disease , bioinformatics , hippocampal formation , biology , psychiatry , paleontology

Acute stress provides many beneficial effects whereas chronic stress contributes to a variety of human health issues including anxiety, depression, gastrointestinal problems, cardiac disease, sleep disorders and obesity. The goal of this work was to identify, using a rodent model, hippocampal gene signatures associated with prolonged chronic stress representing candidate biomarkers and therapeutic targets for early diagnosis and pharmacological intervention for stress induced disease.

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