Open AccessExploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians
Author(s) -
Kevin C. Brown,
Mina C. Hosseinipour,
Janelle M. Hoskins,
Ranjit K. Thirumaran,
Hsiao-Chuan Tien,
Ralf Weigel,
Jean Tauzie,
Ida Shumba,
Jatinder K. Lamba,
Erin G. Schuetz,
Howard L. McLeod,
Angela D. M. Kashuba,
Amanda Corbett
Publication year - 2012
Publication title -
pharmacogenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 91
eISSN - 1744-8042
pISSN - 1462-2416
DOI - 10.2217/pgs.11.132
Subject(s) - nevirapine , cyp2b6 , cyp3a4 , pharmacogenetics , constitutive androstane receptor , genotype , pharmacokinetics , pregnane x receptor , cyp2a6 , single nucleotide polymorphism , pharmacology , allele , cyp3a , cyp3a5 , biology , medicine , cytochrome p450 , genetics , gene , viral load , nuclear receptor , metabolism , virus , antiretroviral therapy , transcription factor
Genetic polymorphisms have the potential to influence drug metabolism and vary among ethnic groups. This study evaluated the correlation of genetic polymorphisms with nevirapine pharmacokinetics exposure in Malawians.