Further evidence for the association of GAL , GALR1 and NPY1R variants with Opioid Dependence | Zendy

Matthew Randesi | Zendy; Orna Levran | Zendy; Wim van den Brink | Zendy; Peter Blanken | Zendy; Jan M. van Ree | Zendy; Jürg Ott | Zendy; Mary Jeanne Kreek | Zendy

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Further evidence for the association of GAL , GALR1 and NPY1R variants with Opioid Dependence

Author(s) -

Matthew Randesi,

Orna Levran,

Wim van den Brink,

Peter Blanken,

Jan M. van Ree,

Jürg Ott,

Mary Jeanne Kreek

Publication year - 2020

Publication title -

pharmacogenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.541

H-Index - 91

eISSN - 1744-8042

pISSN - 1462-2416

DOI - 10.2217/pgs-2020-0045

Subject(s) - heroin , snp , opioid , single nucleotide polymorphism , addiction , genetic association , methadone maintenance , medicine , methadone , association (psychology) , heroin addiction , gene , psychiatry , clinical psychology , pharmacology , genetics , psychology , drug , biology , genotype , receptor , psychotherapist

Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R / GAL rs4691910/rs1893679, NPY1R / GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

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