Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts | Zendy

K. C. Gupta | Zendy; Stephanie Mattingly | Zendy; Ralph J. Knipp | Zendy; Kirill A. Afonin | Zendy; Mathias Viard | Zendy; Joseph T Bergman | Zendy; Marissa Stepler | Zendy; Michael H. Nantz | Zendy; Anu Puri | Zendy; Bruce A. Shapiro | Zendy

Open Access

Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts

Author(s) -

K. C. Gupta,

Stephanie Mattingly,

Ralph J. Knipp,

Kirill A. Afonin,

Mathias Viard,

Joseph T Bergman,

Marissa Stepler,

Michael H. Nantz,

Anu Puri,

Bruce A. Shapiro

Publication year - 2015

Publication title -

nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.947

H-Index - 109

eISSN - 1748-6963

pISSN - 1743-5889

DOI - 10.2217/nnm.15.105

Subject(s) - chemistry , nucleic acid , degree of unsaturation , transfection , biochemistry , ether , liposome , biophysics , stereochemistry , organic chemistry , gene , biology

To evaluate the structure-activity relationship of oxime ether lipids (OELs) containing modifications in the hydrophobic domains (chain length, degree of unsaturation) and hydrophilic head groups (polar domain hydroxyl groups) toward complex formation with siRNA molecules and siRNA delivery efficiency of resulting complexes to a human breast cancer cell line (MDA-MB-231).

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