Open AccessOxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts
Author(s) -
K. C. Gupta,
Stephanie J. Mattingly,
Ralph J. Knipp,
Kirill A. Afonin,
Mathias Viard,
Joseph T Bergman,
Marissa Stepler,
Michael H. Nantz,
Anu Puri,
Bruce A. Shapiro
Publication year - 2015
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm.15.105
Subject(s) - chemistry , nucleic acid , degree of unsaturation , transfection , biochemistry , ether , liposome , biophysics , stereochemistry , organic chemistry , gene , biology
To evaluate the structure-activity relationship of oxime ether lipids (OELs) containing modifications in the hydrophobic domains (chain length, degree of unsaturation) and hydrophilic head groups (polar domain hydroxyl groups) toward complex formation with siRNA molecules and siRNA delivery efficiency of resulting complexes to a human breast cancer cell line (MDA-MB-231).