Open AccessPhytochemical-loaded liposomes for anticancer therapy: an updated review
Author(s) -
Vivek P. Chavda,
Disha R. Vihol,
Bhavya Mehta,
Dhvanit I. Shah,
Manan Patel,
Lalitkumar K. Vora,
Miguel Pereira-Silva,
Ana Cláudia PaivaSantos
Publication year - 2022
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2021-0463
Subject(s) - phytochemical , medicine , liposome , cancer , adverse effect , cancer therapy , pharmacology , bioavailability , traditional medicine , biology , biochemistry
The major obstacles observed in current chemotherapy are severe adverse effects, narrow therapeutic indexes and multidrug resistance. Anticancer phytochemicals are extracted and purified from natural plants, providing alternative therapeutic approaches with recognized biomedical benefits. However, poor bioavailability, high dose requirements and non-specific targeting have made those molecules less effective. To tackle those issues, liposomal nanovesicles for phytochemical delivery are taken into consideration for improving the therapeutic effectiveness by increasing transportation across cell barriers and conferring attractive cancer-specific targeting capabilities. In the present review, the liposomal approaches of anticancer phytochemicals are discussed, and recent advances in these formulations applied to cancer phytotherapy are further reviewed by an informed approach.