Open AccessTherapeutic targets and nanomaterial-based therapies for mitigation of secondary injury after spinal cord injury
Author(s) -
Jun Gao,
Minkyung Khang,
Zhen Liao,
Megan Ryan Detloff,
Jeoung Soo Lee
Publication year - 2021
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2021-0113
Subject(s) - spinal cord injury , medicine , oxidative stress , spinal cord , inflammatory response , inflammation , neuroscience , immunology , biology , psychiatry
Spinal cord injury (SCI) and the resulting neurological trauma commonly result in complete or incomplete neurological dysfunction and there are few effective treatments for primary SCI. However, the following secondary SCI, including the changes of microvasculature, inflammatory response and oxidative stress around the injury site, may provide promising therapeutic targets. The advances of nanomaterials hold promise for delivering therapeutics to alleviate secondary SCI and promote functional recovery. In this review, we highlight recent achievements of nanomaterial-based therapy, specifically targeting blood-spinal cord barrier disruption, mitigation of the inflammatory response and lightening of oxidative stress after spinal cord injury.