Open AccessGenetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field
Author(s) -
SeungHyun Yang,
Byeunghoon Kang,
Yuna Choi,
Hyun Wook Rho,
HoYoung Son,
Yong Min Huh
Publication year - 2021
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0399
Subject(s) - wnt signaling pathway , in vivo , magnetic field , glioblastoma , cancer research , in vitro , nuclear magnetic resonance , magnetic nanoparticles , microbiology and biotechnology , chemistry , materials science , biology , nanoparticle , signal transduction , nanotechnology , physics , biochemistry , quantum mechanics
Aim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. Methods: U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo. Results: LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. Conclusion: When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.